In-silico modeling of early-stage biofilm formation

Bacteria can form biofilms in different environmental conditions, e.g. pH, temperature, nutrients, etc. Biofilm growth, therefore, is an extremely robust process. Because of this, while biofilm growth a complex process affected by several variables, insights into formation could be obtained studying simple schematic models. In this manuscript, we describe hybrid molecular dynamics and Monte Carlo model for the simulation early stage biofilm, to explicitly demonstrate that it possible account most processes expected relevant. The simulations reproduction bacteria, their interaction motility, synthesis extracellular polymeric substances exopolisaccharide trails. We effect these on biofilms, two dimensions, also discuss preliminary three-dimensional results.